UV Spectrophotometric method has been developed for simultaneous estimation of Cefixime (CEF) and Linezolid (LNZ) in bulk drug and combined tablet dosage form. This method utilizes methanol as a solvent and λmax of Cefixime and Linezolid selected for analysis was found to be 290 nm and 259 nm respectively. Linearity was observed in the concentration range of 6-14 μg/ml for Cefixime (r2=0.999) and 7-15 μg/ml for Linezolid (r2=0.999).The method was validated statistically and by recovery studies. The mean % recovery was 99.46-101.11 % and 99.34-101.77 % for Cefixime and Linezolid respectively. The proposed procedure was successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The results were found to be within acceptance criteria according to ICH guideline. This method was simple, rapid, accurate and sensitive.
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